Manufacturing Process Development for Belzutifan, Part 3: Completing a Streamlined Through-Process with a Safe and Scalable Oxidation

We report the development of a modified Kornblum oxidation mediated by 2-picoline N-oxide for the synthesis of belzutifan that circumvented safety and stench problems associated with the original clinical supply route conditions. A robust quench for the crude bromination stream with 1,3-dimethoxyben...

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Veröffentlicht in:	Organic process research & development 2022-03, Vol.26 (3), p.525-532
Hauptverfasser:	Chen, Zhiwei, Salehi Marzijarani, Nastaran, Quirie, Scott, Pirrone, Gregory F, Dalby, Stephen M, Wang, Tao, Kim, Jungchul, Peng, Feng, Fine, Adam J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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