Crystallization Process Development for the Final Step of the Biocatalytic Synthesis of Islatravir: Comprehensive Crystal Engineering for a Low-Dose Drug

Islatravir (MK-8591), a highly potent nucleoside reverse transcriptase translocation inhibitor, is being developed to stem the spread of global HIV infections. Following a nine-enzyme in vitro synthesis of islatravir from 2-ethynylglycerol without intermediate isolation, a crude active pharmaceutica...

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Veröffentlicht in:	Organic process research & development 2021-02, Vol.25 (2), p.308-317
Hauptverfasser:	Sirota, Eric, Kwok, Thomas, Varsolona, Richard J, Whittaker, Aaron, Andreani, Teresa, Quirie, Scott, Margelefsky, Eric, Lamberto, David J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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