Application of C–H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib

This paper describes the development of an improved and scalable method for the manufacture of nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor. Incorporation of three consecutive catalytic reactions, including a palladium-catalyzed C–H functionalization and an iridium-catalyzed borylati...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Organic process research & development 2021-03, Vol.25 (3), p.529-540
Hauptverfasser:	Bream, Robert N, Clark, Hugh, Edney, Dean, Harsanyi, Antal, Hayler, John, Ironmonger, Alan, Mc Cleary, Nadine, Phillips, Natalie, Priestley, Catherine, Roberts, Alastair, Rushworth, Philip, Szeto, Peter, Webb, Michael R, Wheelhouse, Katherine
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!