Synthesis of Vixotrigine, a Voltage- and Use-Dependent Sodium Channel Blocker. Part 2: Development of a Late-Stage Process

As vixotrigine (1) entered a later clinical phase for trigeminal neuralgia ( Zakrzewska, J. M. ; et al. Lancet Neurol. 2017, 16, 291−300 ), the development of a sustainable late-stage process was required to meet the supply needs for formulation optimization, phase 3 clinical trials, and registratio...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Organic process research & development 2020-12, Vol.24 (12), p.2814-2829
Hauptverfasser:	Chen, Robbie, Couming, Vincent, Guzowski, John, Irdam, Erwin, Kiesman, William F, Kwok, Daw-Iong Albert, Liang, Wenli, Mack, Tamera, O’Brien, Erin M, Opalka, Suzanne M, Patience, Daniel, Sahli, Stefan, Walker, Donald G, Osei-Yeboah, Frederick, Gu, Chaozhan, Zhang, Xin, Stöckli, Markus, Stucki, Thiemo, Matzinger, Hanspeter, Kuhn, Roman, Thut, Michael, Grohmann, Markus, Haefner, Benjamin, Lotz, Joerg, Nonnenmacher, Michael, Cerea, Paolangelo
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!