General Method for Quantitation of Organic Hydroperoxides

General Method for Quantitation of Organic Hydroperoxides

The utility of peroxides in synthetic organic chemistry is tied to significant safety risks posed by their handling, storage, and disposal. Although guidelines exist, a lack of reliable methods for quantitation of low levels of these species has been a major impediment to establishing data-driven sa...

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Veröffentlicht in:Organic process research & development 2020-07, Vol.24 (7), p.1321-1327
Hauptverfasser: Beutner, Gregory L, Ayers, Sloan, Chen, Tao, Leung, Simon W, Tai, Hua Chia, Wang, Qinggang
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container_issue 7
container_start_page 1321
container_title Organic process research & development
container_volume 24
creator Beutner, Gregory L
Ayers, Sloan
Chen, Tao
Leung, Simon W
Tai, Hua Chia
Wang, Qinggang
description The utility of peroxides in synthetic organic chemistry is tied to significant safety risks posed by their handling, storage, and disposal. Although guidelines exist, a lack of reliable methods for quantitation of low levels of these species has been a major impediment to establishing data-driven safety guidelines and protocols. This paper discloses a general and reliable liquid chromatography-ultraviolet (LC-UV)-based method for the detection of a wide range of commonly encountered organic hydroperoxides. The implications of this method for safety concerns around trace peroxides are also discussed, supported by modern thermochemical analysis.
doi_str_mv 10.1021/acs.oprd.0c00251
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