Practical and Scalable Synthesis of a Glucokinase Activator via One-Pot Difluorination and Julia Olefination

We describe the process research and development of a practical synthesis of glucokinase activator 1 as a potential drug for treating type 2 diabetes mellitus. The key structure, a 3,4-cis-difluorinated cyclopentane moiety, was constructed via diastereoselective epoxidation, followed by one-pot difl...

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Veröffentlicht in:	Organic process research & development 2020-07, Vol.24 (7), p.1294-1303
Hauptverfasser:	Tsuchiya, Hideyoshi, Iwamoto, Minoru, Miyamoto, Hidetoshi, Sakumoto, Chihiro, Tamamizu, Tokihiko, Inoshita, Yasuo, Koyama, Yuzo, Sato, Yoshinori, Kumamoto, Takuya
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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