Large-Scale Practical Synthesis of Boc-Protected 4‑Fluoro‑l‑Proline

A large-scale synthesis process of N-Boc-4-fluoro-l-proline (1) from N-Boc-4-hydroxy-l-proline methyl ester (2) using nosyl fluoride (13) as a deoxyfluorinating agent has been developed. An eco-friendly and large-scale feasible process using a single solvent was developed to afford moderate yields o...

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Veröffentlicht in:	Organic process research & development 2020-09, Vol.24 (9), p.1609-1613
Hauptverfasser:	Tamboli, Yasinalli, Kashid, Bharat, Yadav, Ram Prasad, Rafeeq, Mohammad, Merwade, Arvind Y
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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