SnS 2 QDs@MXene Ohmic Junction-Based Surface Plasmon Coupling ECL Sensor to Detect Saliva Exosome for the Diagnosis of Childhood Asthma
This study represents a novel surface plasmon coupling electrochemiluminescence (SPC-ECL) method for detecting salivary exosomes and the diagnosis of childhood asthma. First, SnS QDs@MXene Ohmic junctions was developed as efficient ECL emitters. The Ohmic junction provided a low resistance to reduce...
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| Veröffentlicht in: | Nano letters 2024-12, Vol.24 (49), p.15878 |
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| container_issue | 49 |
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| container_title | Nano letters |
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| creator | Li, Zhenrun Liang, Zihui Wang, Peilin Li, Wenyan Li, Yameng Liu, Ning Ma, Qiang |
| description | This study represents a novel surface plasmon coupling electrochemiluminescence (SPC-ECL) method for detecting salivary exosomes and the diagnosis of childhood asthma. First, SnS
QDs@MXene Ohmic junctions was developed as efficient ECL emitters. The Ohmic junction provided a low resistance to reduce the contact resistance and improve charge injection efficiency, which enhanced the ECL signal by 2.76 times. Furthermore, the self-assembled surface plasmonic Bi@SiO
array was prepared. When the ECL of SnS
QDs@MXene resonated with the electronic oscillations in the Bi@SiO
NPs array, the luminescence intensity was enhanced and regulated into the directionally polarized signal by the SPC-ECL effect. Remarkably, the detection of CD9-exosomes in saliva was achieved successfully based on the above sensing system, which can be used to analysis the acute exacerbation and chronic persistence of childhood asthma. |
| doi_str_mv | 10.1021/acs.nanolett.4c04939 |
| format | Article |
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QDs@MXene Ohmic junctions was developed as efficient ECL emitters. The Ohmic junction provided a low resistance to reduce the contact resistance and improve charge injection efficiency, which enhanced the ECL signal by 2.76 times. Furthermore, the self-assembled surface plasmonic Bi@SiO
array was prepared. When the ECL of SnS
QDs@MXene resonated with the electronic oscillations in the Bi@SiO
NPs array, the luminescence intensity was enhanced and regulated into the directionally polarized signal by the SPC-ECL effect. Remarkably, the detection of CD9-exosomes in saliva was achieved successfully based on the above sensing system, which can be used to analysis the acute exacerbation and chronic persistence of childhood asthma.</description><identifier>ISSN: 1530-6984</identifier><identifier>EISSN: 1530-6992</identifier><identifier>DOI: 10.1021/acs.nanolett.4c04939</identifier><identifier>PMID: 39576655</identifier><language>eng</language><publisher>United States</publisher><subject>Asthma - diagnosis ; Asthma - metabolism ; Biosensing Techniques - methods ; Child ; Electrochemical Techniques - methods ; Exosomes - chemistry ; Exosomes - metabolism ; Humans ; Luminescent Measurements - methods ; Quantum Dots - chemistry ; Saliva - chemistry ; Saliva - metabolism ; Silicon Dioxide - chemistry ; Sulfides - chemistry ; Surface Plasmon Resonance - methods ; Tin Compounds - chemistry</subject><ispartof>Nano letters, 2024-12, Vol.24 (49), p.15878</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c685-d1f4978eb5f8f4b5a637d71e325a7863bc5c68a5f3d6cfad5efdab72001c54423</cites><orcidid>0000-0003-4841-5005</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2765,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39576655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Zhenrun</creatorcontrib><creatorcontrib>Liang, Zihui</creatorcontrib><creatorcontrib>Wang, Peilin</creatorcontrib><creatorcontrib>Li, Wenyan</creatorcontrib><creatorcontrib>Li, Yameng</creatorcontrib><creatorcontrib>Liu, Ning</creatorcontrib><creatorcontrib>Ma, Qiang</creatorcontrib><title>SnS 2 QDs@MXene Ohmic Junction-Based Surface Plasmon Coupling ECL Sensor to Detect Saliva Exosome for the Diagnosis of Childhood Asthma</title><title>Nano letters</title><addtitle>Nano Lett</addtitle><description>This study represents a novel surface plasmon coupling electrochemiluminescence (SPC-ECL) method for detecting salivary exosomes and the diagnosis of childhood asthma. First, SnS
QDs@MXene Ohmic junctions was developed as efficient ECL emitters. The Ohmic junction provided a low resistance to reduce the contact resistance and improve charge injection efficiency, which enhanced the ECL signal by 2.76 times. Furthermore, the self-assembled surface plasmonic Bi@SiO
array was prepared. When the ECL of SnS
QDs@MXene resonated with the electronic oscillations in the Bi@SiO
NPs array, the luminescence intensity was enhanced and regulated into the directionally polarized signal by the SPC-ECL effect. Remarkably, the detection of CD9-exosomes in saliva was achieved successfully based on the above sensing system, which can be used to analysis the acute exacerbation and chronic persistence of childhood asthma.</description><subject>Asthma - diagnosis</subject><subject>Asthma - metabolism</subject><subject>Biosensing Techniques - methods</subject><subject>Child</subject><subject>Electrochemical Techniques - methods</subject><subject>Exosomes - chemistry</subject><subject>Exosomes - metabolism</subject><subject>Humans</subject><subject>Luminescent Measurements - methods</subject><subject>Quantum Dots - chemistry</subject><subject>Saliva - chemistry</subject><subject>Saliva - metabolism</subject><subject>Silicon Dioxide - chemistry</subject><subject>Sulfides - chemistry</subject><subject>Surface Plasmon Resonance - methods</subject><subject>Tin Compounds - chemistry</subject><issn>1530-6984</issn><issn>1530-6992</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMlOwzAURS0EolD4A4TeD6TYsZ1hR0nLpKKC0gW7yPHQBCV2FacIvoDfplWH1bvSu-cuDkI3BI8IDsmdkH5khXWN7vsRk5ilND1BF4RTHERpGp4ec8IG6NL7L4xxSjk-RwOa8jiKOL9Af7nNIYSPib9_-9RWw7xqawmvayv72tngQXitIF93RkgN743wrbOQufWqqe0SptkMcm2966B3MNG9lj3koqm_BUx_nHetBrN9VhomtVha52sPzkBW1Y2qnFMw9n3Viit0ZkTj9fX-DtHicbrInoPZ_OklG88CGSU8UMSwNE50yU1iWMlFRGMVE01DLuIkoqXkm57ghqpIGqG4NkqUcYgxkZyxkA4R283KznnfaVOsuroV3W9BcLHVWmy0FgetxV7rBrvdYat12Wp1hA4e6T-QYnhx</recordid><startdate>20241211</startdate><enddate>20241211</enddate><creator>Li, Zhenrun</creator><creator>Liang, Zihui</creator><creator>Wang, Peilin</creator><creator>Li, Wenyan</creator><creator>Li, Yameng</creator><creator>Liu, Ning</creator><creator>Ma, Qiang</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-4841-5005</orcidid></search><sort><creationdate>20241211</creationdate><title>SnS 2 QDs@MXene Ohmic Junction-Based Surface Plasmon Coupling ECL Sensor to Detect Saliva Exosome for the Diagnosis of Childhood Asthma</title><author>Li, Zhenrun ; Liang, Zihui ; Wang, Peilin ; Li, Wenyan ; Li, Yameng ; Liu, Ning ; Ma, Qiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c685-d1f4978eb5f8f4b5a637d71e325a7863bc5c68a5f3d6cfad5efdab72001c54423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Asthma - diagnosis</topic><topic>Asthma - metabolism</topic><topic>Biosensing Techniques - methods</topic><topic>Child</topic><topic>Electrochemical Techniques - methods</topic><topic>Exosomes - chemistry</topic><topic>Exosomes - metabolism</topic><topic>Humans</topic><topic>Luminescent Measurements - methods</topic><topic>Quantum Dots - chemistry</topic><topic>Saliva - chemistry</topic><topic>Saliva - metabolism</topic><topic>Silicon Dioxide - chemistry</topic><topic>Sulfides - chemistry</topic><topic>Surface Plasmon Resonance - methods</topic><topic>Tin Compounds - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Zhenrun</creatorcontrib><creatorcontrib>Liang, Zihui</creatorcontrib><creatorcontrib>Wang, Peilin</creatorcontrib><creatorcontrib>Li, Wenyan</creatorcontrib><creatorcontrib>Li, Yameng</creatorcontrib><creatorcontrib>Liu, Ning</creatorcontrib><creatorcontrib>Ma, Qiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Nano letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Zhenrun</au><au>Liang, Zihui</au><au>Wang, Peilin</au><au>Li, Wenyan</au><au>Li, Yameng</au><au>Liu, Ning</au><au>Ma, Qiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SnS 2 QDs@MXene Ohmic Junction-Based Surface Plasmon Coupling ECL Sensor to Detect Saliva Exosome for the Diagnosis of Childhood Asthma</atitle><jtitle>Nano letters</jtitle><addtitle>Nano Lett</addtitle><date>2024-12-11</date><risdate>2024</risdate><volume>24</volume><issue>49</issue><spage>15878</spage><pages>15878-</pages><issn>1530-6984</issn><eissn>1530-6992</eissn><abstract>This study represents a novel surface plasmon coupling electrochemiluminescence (SPC-ECL) method for detecting salivary exosomes and the diagnosis of childhood asthma. First, SnS
QDs@MXene Ohmic junctions was developed as efficient ECL emitters. The Ohmic junction provided a low resistance to reduce the contact resistance and improve charge injection efficiency, which enhanced the ECL signal by 2.76 times. Furthermore, the self-assembled surface plasmonic Bi@SiO
array was prepared. When the ECL of SnS
QDs@MXene resonated with the electronic oscillations in the Bi@SiO
NPs array, the luminescence intensity was enhanced and regulated into the directionally polarized signal by the SPC-ECL effect. Remarkably, the detection of CD9-exosomes in saliva was achieved successfully based on the above sensing system, which can be used to analysis the acute exacerbation and chronic persistence of childhood asthma.</abstract><cop>United States</cop><pmid>39576655</pmid><doi>10.1021/acs.nanolett.4c04939</doi><orcidid>https://orcid.org/0000-0003-4841-5005</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1530-6984 |
| ispartof | Nano letters, 2024-12, Vol.24 (49), p.15878 |
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| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Asthma - diagnosis Asthma - metabolism Biosensing Techniques - methods Child Electrochemical Techniques - methods Exosomes - chemistry Exosomes - metabolism Humans Luminescent Measurements - methods Quantum Dots - chemistry Saliva - chemistry Saliva - metabolism Silicon Dioxide - chemistry Sulfides - chemistry Surface Plasmon Resonance - methods Tin Compounds - chemistry |
| title | SnS 2 QDs@MXene Ohmic Junction-Based Surface Plasmon Coupling ECL Sensor to Detect Saliva Exosome for the Diagnosis of Childhood Asthma |
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