Insights into the Dissolution Behavior of Ledipasvir–Copovidone Amorphous Solid Dispersions: Role of Drug Loading and Intermolecular Interactions

The generation of a colloidal drug-rich phase by dissolving an amorphous solid dispersion (ASD) is thought to have a positive impact on oral absorption and bioavailability. Thus, understanding which formulations generate these species is important. In this study, ledipasvir–copovidone ASDs, with and...

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Veröffentlicht in:	Molecular pharmaceutics 2019-12, Vol.16 (12), p.5054-5067
Hauptverfasser:	Que, Chailu, Lou, Xiaochun, Zemlyanov, Dmitry Y, Mo, Huaping, Indulkar, Anura S, Gao, Yi, Zhang, Geoff G. Z, Taylor, Lynne S
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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