Vitamin E‑Conjugated Phosphopeptide Inhibitor of the Polo-Box Domain of Polo-Like Kinase 1

Polo-like kinase 1 (Plk1) regulates cell cycle and cell proliferation, and is currently considered a potential biomarker in clinical trials for many cancers. A characteristic feature of Plks is their C-terminal polo-box domain (PBD). Pro-Leu-His-Ser-pThr (PLHS[pT])the phosphopeptide inhibitor of t...

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Veröffentlicht in:	Molecular pharmaceutics 2019-12, Vol.16 (12), p.4867-4877
Hauptverfasser:	Yim, Min Su, Soung, Nak Kyun, Han, Eun Hee, Min, Jin-Young, Han, HoJin, Son, Eun-Ju, Kim, Hak Nam, Kim, BoYeon, Bang, Jeong Kyu, Ryu, Eun kyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Cell Cycle Checkpoints - drug effects Cell Cycle Proteins - metabolism Cell Survival - drug effects Enzyme Activation - drug effects Flow Cytometry HeLa Cells Humans Mitosis - drug effects Phosphopeptides - chemistry Polo-Like Kinase 1 Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Vitamin E - chemistry
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