Intravitreal Pharmacokinetics in Mice: SPECT/CT Imaging and Scaling to Rabbits and Humans

Preclinical in vivo tests of retinal drug responses are carried out in mice and rats, often after intravitreal injections. However, quantitative pharmacokinetics in the mouse eye is poorly understood. Ocular pharmacokinetics studies are usually done in rabbits. We investigated elimination of three c...

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Veröffentlicht in:	Molecular pharmaceutics 2019-10, Vol.16 (10), p.4399-4404
Hauptverfasser:	Schmitt, Mechthild, Hippeläinen, Eero, Raviña, Manuela, Arango-Gonzalez, Blanca, Antopolsky, Maxim, Vellonen, Kati-Sisko, Airaksinen, Anu J, Urtti, Arto
Format:	Artikel
Sprache:	eng
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