Molecular Interactions in Posaconazole Amorphous Solid Dispersions from Two-Dimensional Solid-State NMR Spectroscopy

Molecular interactions between the active pharmaceutical ingredient and polymer have potentially substantial impacts on the physical stability of amorphous solid dispersions (ASDs), presumably by manipulating molecular mobility and miscibility. However, structural details for understanding the natur...

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Veröffentlicht in:	Molecular pharmaceutics 2019-06, Vol.16 (6), p.2579-2589
Hauptverfasser:	Lu, Xingyu, Huang, Chengbin, Lowinger, Michael B, Yang, Fengyuan, Xu, Wei, Brown, Chad D, Hesk, David, Koynov, Athanas, Schenck, Luke, Su, Yongchao
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon - chemistry Colloids - chemistry Hydrogen Bonding Magnetic Resonance Spectroscopy Triazoles - chemistry
Online-Zugang:	Volltext
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