Charge Reversible and Mitochondria/Nucleus Dual Target Lipid Hybrid Nanoparticles To Enhance Antitumor Activity of Doxorubicin

The experiment aims to increase antitumor activity while decreasing the systemic toxicity of doxorubicin (DOX). Charge reversible and mitochondria/nucleus dual target lipid hybrid nanoparticles (LNPs) was prepared. The in vitro experimental results indicated that LNPs released more amount of DOX in...

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Veröffentlicht in:	Molecular pharmaceutics 2018-03, Vol.15 (3), p.1296-1308
Hauptverfasser:	Song, Yan-feng, Liu, Dao-zhou, Cheng, Ying, Teng, Zeng-hui, Cui, Han, Liu, Miao, Zhang, Bang-le, Mei, Qi-bing, Zhou, Si-yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - administration & dosage Cell Line, Tumor Cell Nucleus - drug effects Doxorubicin - administration & dosage Drug Carriers - chemistry Female Humans Hydrogen-Ion Concentration Lipids - chemistry Male Membrane Potential, Mitochondrial - drug effects Mice Mice, Nude Mitochondria - drug effects Nanoparticles - chemistry Neoplasms - drug therapy Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Xenograft Model Antitumor Assays
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