Smart Porous Silicon Nanoparticles with Polymeric Coatings for Sequential Combination Therapy

In spite of the advances in drug delivery, the preparation of smart nanocomposites capable of precisely controlled release of multiple drugs for sequential combination therapy is still challenging. Here, a novel drug delivery nanocomposite was prepared by coating porous silicon (PSi) nanoparticles w...

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Veröffentlicht in:	Molecular pharmaceutics 2015-11, Vol.12 (11), p.4038-4047
Hauptverfasser:	Xu, Wujun, Thapa, Rinez, Liu, Dongfei, Nissinen, Tuomo, Granroth, Sari, Närvänen, Ale, Suvanto, Mika, Santos, Hélder A, Lehto, Vesa-Pekka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - chemistry Antineoplastic Combined Chemotherapy Protocols - pharmacology Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Coated Materials, Biocompatible - chemistry Doxorubicin - administration & dosage Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Delivery Systems Drug Liberation HeLa Cells Humans Macrophages - cytology Macrophages - drug effects Mice Nanocomposites - chemistry Nanoparticles - chemistry Paclitaxel - administration & dosage Polymers - chemistry Porosity Silicon - chemistry
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