Effect of the Conjugation Density of Triphenylphosphonium Cation on the Mitochondrial Targeting of Poly(amidoamine) Dendrimers

Many clinically relevant diseases with known poor therapeutic outcomes, including cancer and neurodegenerative disorders, have been directly linked to mitochondrial dysfunction. The ability to efficiently target therapeutics to intracellular organelles such as mitochondria may represent new opportun...

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Veröffentlicht in:	Molecular pharmaceutics 2015-08, Vol.12 (8), p.3043-3053
Hauptverfasser:	Bielski, Elizabeth R, Zhong, Qian, Brown, Matthew, da Rocha, Sandro R. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Dendrimers - pharmacology Drug Carriers - chemistry Drug Delivery Systems Humans Lung Neoplasms - drug therapy Lung Neoplasms - pathology Mitochondria - drug effects Mitochondria - pathology Organophosphorus Compounds - chemistry Polyamines - pharmacology Polyethylene Glycols - chemistry Tumor Cells, Cultured
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