The Chemistry of Creating Chemically Programmed Antibodies (cPAbs): Site-Specific Bioconjugation of Small Molecules

Small-molecule drugs have been employed for years as therapeutics in the pharmaceutical industry. However, small-molecule drugs typically have short in vivo half-lives which is one of the largest impediments to the success of many potentially valuable pharmacologically active small molecules. The un...

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Veröffentlicht in:	Molecular pharmaceutics 2023-02, Vol.20 (2), p.853-874
Hauptverfasser:	Aigbogun, Omozojie P., Phenix, Christopher P., Krol, Ed S., Price, Eric W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - chemistry Antigens Immunoconjugates - chemistry Immunoglobulin G - chemistry
Online-Zugang:	Volltext
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