Molecular-Level Examination of Amorphous Solid Dispersion Dissolution

Amorphous solid dispersions (ASDs) are commonly used to orally deliver small-molecule drugs that are poorly water-soluble. ASDs consist of drug molecules in the amorphous form which are dispersed in a hydrophilic polymer matrix. Producing a high-performance ASD is critical for effective drug deliver...

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Veröffentlicht in:	Molecular pharmaceutics 2021-11, Vol.18 (11), p.3999-4014
Hauptverfasser:	Faiz Afzal, Mohammad Atif, Lehmkemper, Kristin, Sobich, Ekaterina, Hughes, Thomas F, Giesen, David J, Zhang, Teng, Krauter, Caroline M, Winget, Paul, Degenhardt, Matthias, Kyeremateng, Samuel O, Browning, Andrea R, Shelley, John C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Availability Chemistry, Pharmaceutical Drug Compounding - methods Drug Liberation Excipients - chemistry Hydrophobic and Hydrophilic Interactions Molecular Dynamics Simulation Polymers - chemistry Solubility Spectroscopy, Fourier Transform Infrared
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