Effect of Oxime Encapsulation on Acetylcholinesterase Reactivation: Pharmacokinetic Study of the Asoxime–Cucurbit[7]uril Complex in Mice Using Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry

Oxime-based molecules are used for the treatment of patients to reactivate acetylcholinesterase (AChE) function after organophosphate intoxication. However, their efficacy is limited by low penetration through the blood–brain barrier and fast elimination. In this work, the cucurbit[7]­uril (CB[7]) c...

Ausführliche Beschreibung