Branched-Chain Amino Acids as Predictors for Individual Differences of Cisplatin Nephrotoxicity in Rats: A Pharmacometabonomics Study

Nephrotoxicity is the dose-limiting adverse effect of cisplatin with large individual differences. Up to now, little has been done on how to recognize and predict the individual differences in either preclinical or clinical research. In the present study, important postdose indicators were screened...

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Veröffentlicht in:	Journal of proteome research 2017-04, Vol.16 (4), p.1753-1762
Hauptverfasser:	Zhang, Pei, Li, Wei, Chen, Jiaqing, Li, Ruiting, Zhang, Zunjian, Huang, Yin, Xu, Fengguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids, Branched-Chain - blood Animals Antineoplastic Agents - adverse effects Cisplatin - adverse effects Humans Kidney - metabolism Kidney - pathology Mass Spectrometry Metabolomics Neoplasms - blood Neoplasms - drug therapy Neoplasms - pathology Precision Medicine Rats
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