Examining the Ways To Bend and Break Reaction Pathways Using Mechanochemistry

Mechanical forces can lead to qualitative changes in reaction mechanism, which depend on the specific mode of force induction and inherent chemistries of the mechanophore. To demonstrate these effects at an atomistic level, three challenging mechanochemical transformations of recent interest are her...

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Veröffentlicht in:Journal of physical chemistry. C 2018-03, Vol.122 (12), p.6996-7004
Hauptverfasser: Roessler, Allison G, Zimmerman, Paul M
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Zimmerman, Paul M
description Mechanical forces can lead to qualitative changes in reaction mechanism, which depend on the specific mode of force induction and inherent chemistries of the mechanophore. To demonstrate these effects at an atomistic level, three challenging mechanochemical transformations of recent interest are herein studied: spiropyran ring opening, flex-activated small molecule release, and cyclopropane ring opening. These examples show that mechanical load can eliminate intermediates and transition states along a reaction path, preactivate reactions where the force is not parallel to the reaction path, and modulate force conveyance to the mechanophore in a polymer-dependent fashion. Two different merocyanin products were identifiedcis and trans isomersfrom the spiropyran ring-opening reaction, and tuning the magnitude of the force allows for selection of one over the other. The reaction involving oxanorbornadiene where bonds perpendicular to the force are flexed through angular distortions has the interesting property that while the central bond contracts, the overall molecule is lengthened to effect activation. Cyclopropane ring openings demonstrate that the larger the extension of the mechanophore, determined by the rigidity of the polymer backbone under applied force, the larger the change in activation barrier. In this case, the application of a force represents a preactivation mechanism where the initial structure rises in energy, while the transition state stays relatively constant. For these three motifs, the reaction paths are readily uncovered using the growing string method, showing it to be a widely useful tool for studying mechanochemistry.
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