Insights into the Role of Side-Chain Team Work in nDsbD Ox/Red Proteins: Mechanism of Substrate Binding

N-terminal disulfide bond oxidoreductase (nDsbD ) proteins display divergent substrate binding mechanisms depending on the conformational changes to the Phe cap, which is also dependent on the disulfide redox state. In nDsbD , the cap dynamics is complex (shows both open/closed Phe cap conformations...

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Veröffentlicht in:	The journal of physical chemistry. B 2024-10, Vol.128 (43), p.10541-10552
Hauptverfasser:	Nair, Aparna G, Anjukandi, Padmesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Catalytic Domain Disulfides - chemistry Molecular Dynamics Simulation Oxidation-Reduction Oxidoreductases - chemistry Oxidoreductases - metabolism Protein Binding Protein Conformation Substrate Specificity
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