Discovery of the Streptoketides by Direct Cloning and Rapid Heterologous Expression of a Cryptic PKS II Gene Cluster from Streptomyces sp. Tü 6314

Genome sequencing and bioinformatic analysis have identified numerous cryptic gene clusters that have the potential to produce novel natural products. Within this work, we identified a cryptic type II PKS gene cluster (skt) from Streptomyces sp. Tü 6314. Facilitated by linear plus linear homologous...

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Veröffentlicht in:	Journal of organic chemistry 2020-01, Vol.85 (2), p.664-673
Hauptverfasser:	Qian, Zhengyi, Bruhn, Torsten, D’Agostino, Paul M, Herrmann, Alexander, Haslbeck, Martin, Antal, Noémi, Fiedler, Hans-Peter, Brack-Werner, Ruth, Gulder, Tobias A. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Cell Line Chromatography, High Pressure Liquid - methods Cloning, Molecular Gene Expression Regulation, Bacterial Microbial Sensitivity Tests Multigene Family Polyketide Synthases - genetics Polyketides - chemistry Polyketides - isolation & purification Polyketides - pharmacology Spectrum Analysis - methods Streptomyces - enzymology Streptomyces - genetics
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