SO 2 ClF: A Reagent for Controllable Chlorination and Chlorooxidation of Simple Unprotected Indoles

SO 2 ClF: A Reagent for Controllable Chlorination and Chlorooxidation of Simple Unprotected Indoles

Sulfuryl chlorofluoride was first employed as a versatile reagent for controllable chlorination and chlorooxidation of simple unprotected indoles. Three types of products including 3-chloro-indoles, 3-chloro-2-oxindoles, and 3,3-dichloro-2-oxindoles could be selectively obtained in good to excellent...

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Veröffentlicht in:Journal of organic chemistry 2023-04, Vol.88 (7), p.4839-4847
Hauptverfasser: Ma, Tianting, Zheng, Yu, Huang, Shenlin
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container_title Journal of organic chemistry
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creator Ma, Tianting
Zheng, Yu
Huang, Shenlin
description Sulfuryl chlorofluoride was first employed as a versatile reagent for controllable chlorination and chlorooxidation of simple unprotected indoles. Three types of products including 3-chloro-indoles, 3-chloro-2-oxindoles, and 3,3-dichloro-2-oxindoles could be selectively obtained in good to excellent yields by switching the reaction solvents. The present method features easy-to-operate, broad substrate scope, and mild reaction conditions.
doi_str_mv 10.1021/acs.joc.3c00039
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title SO 2 ClF: A Reagent for Controllable Chlorination and Chlorooxidation of Simple Unprotected Indoles
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