In Vitro Antibacterial Activity of Curcumin–Polymyxin B Combinations against Multidrug-Resistant Bacteria Associated with Traumatic Wound Infections
Bacterial infections resulting from nonsurgical traumatic wounds can be life threatening, especially those caused by multidrug-resistant (MDR) bacteria with limited therapeutic options. The antimicrobial activity of polymyxin B (1) and curcumin (2) alone and in combination was determined versus MDR...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2016-06, Vol.79 (6), p.1702-1706 |
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| container_issue | 6 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Betts, Jonathan W Sharili, Amir S La Ragione, Roberto M Wareham, David W |
| description | Bacterial infections resulting from nonsurgical traumatic wounds can be life threatening, especially those caused by multidrug-resistant (MDR) bacteria with limited therapeutic options. The antimicrobial activity of polymyxin B (1) and curcumin (2) alone and in combination was determined versus MDR bacterial isolates associated with traumatic wound infections. Cytotoxicity assays for 1 and 2 were undertaken in keratinocyte cell lines. Minimum inhibitory concentrations of 1 were significantly reduced in the presence of 2 (3- to 10-fold reduction), with synergy observed. Time–kill assays showed the combinations produced bactericidal activity. Cytotoxicity assays indicate the toxicity of 2 was reduced in the presence of 1. |
| doi_str_mv | 10.1021/acs.jnatprod.6b00286 |
| format | Article |
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Cytotoxicity assays indicate the toxicity of 2 was reduced in the presence of 1.</description><subject>Acinetobacter baumannii - drug effects</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Curcumin - pharmacology</subject><subject>Drug Resistance, Multiple, Bacterial - drug effects</subject><subject>Drug Synergism</subject><subject>Humans</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Structure</subject><subject>Polymyxin B - pharmacology</subject><subject>Skin - pathology</subject><subject>Wound Infection - drug therapy</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtOwzAQQC0EgvK5AUK-QMrYjpN0WSo-lUAgxGcZ-RcwauzKdoDuuAMSB-QkBFpYsprNvKeZh9A-gSEBSg6FisMnJ9I8eD0sJACtijU0IJxCVgDl62gApGAZq4p8C23H-AQADEZ8E23Rko44L8gAfUwdvrMpeDx2yUqhkglWzPBYJfts0wL7Bk-6oLrWus-39ys_W7SLV-vwEZ74Vtr-AOtdxOJBWBcTvuhmyerQPWTXJtqYhEv4aGXF4xi9siIZjV9sesQ3QXRtL1D43ndO46lrjPrx7aKNRsyi2VvNHXR7cnwzOcvOL0-nk_F5JtgoT5nmIGAERgjNtOKSlFpVRuclowUpZQGMS9Y0NNdVXnFdVVRKWklCJOTATMl2UL70quBjDKap58G2IixqAvV35rrPXP9mrleZe-xgic072Rr9B_127RdgufCD-y64_ov_nV8HupIC</recordid><startdate>20160624</startdate><enddate>20160624</enddate><creator>Betts, Jonathan W</creator><creator>Sharili, Amir S</creator><creator>La Ragione, Roberto M</creator><creator>Wareham, David W</creator><general>American Chemical Society and American Society of Pharmacognosy</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20160624</creationdate><title>In Vitro Antibacterial Activity of Curcumin–Polymyxin B Combinations against Multidrug-Resistant Bacteria Associated with Traumatic Wound Infections</title><author>Betts, Jonathan W ; Sharili, Amir S ; La Ragione, Roberto M ; Wareham, David W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a394t-d50a090eaad3dc5b17dc8ed4732617b6035b3ff24d8485d882bb28b11b0403e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acinetobacter baumannii - drug effects</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Curcumin - pharmacology</topic><topic>Drug Resistance, Multiple, Bacterial - drug effects</topic><topic>Drug Synergism</topic><topic>Humans</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Structure</topic><topic>Polymyxin B - pharmacology</topic><topic>Skin - pathology</topic><topic>Wound Infection - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Betts, Jonathan W</creatorcontrib><creatorcontrib>Sharili, Amir S</creatorcontrib><creatorcontrib>La Ragione, Roberto M</creatorcontrib><creatorcontrib>Wareham, David W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Betts, Jonathan W</au><au>Sharili, Amir S</au><au>La Ragione, Roberto M</au><au>Wareham, David W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro Antibacterial Activity of Curcumin–Polymyxin B Combinations against Multidrug-Resistant Bacteria Associated with Traumatic Wound Infections</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2016-06-24</date><risdate>2016</risdate><volume>79</volume><issue>6</issue><spage>1702</spage><epage>1706</epage><pages>1702-1706</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><abstract>Bacterial infections resulting from nonsurgical traumatic wounds can be life threatening, especially those caused by multidrug-resistant (MDR) bacteria with limited therapeutic options. The antimicrobial activity of polymyxin B (1) and curcumin (2) alone and in combination was determined versus MDR bacterial isolates associated with traumatic wound infections. Cytotoxicity assays for 1 and 2 were undertaken in keratinocyte cell lines. Minimum inhibitory concentrations of 1 were significantly reduced in the presence of 2 (3- to 10-fold reduction), with synergy observed. Time–kill assays showed the combinations produced bactericidal activity. 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| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2016-06, Vol.79 (6), p.1702-1706 |
| issn | 0163-3864 1520-6025 |
| language | eng |
| recordid | cdi_crossref_primary_10_1021_acs_jnatprod_6b00286 |
| source | MEDLINE; ACS Publications |
| subjects | Acinetobacter baumannii - drug effects Anti-Bacterial Agents - pharmacology Curcumin - pharmacology Drug Resistance, Multiple, Bacterial - drug effects Drug Synergism Humans Microbial Sensitivity Tests Molecular Structure Polymyxin B - pharmacology Skin - pathology Wound Infection - drug therapy |
| title | In Vitro Antibacterial Activity of Curcumin–Polymyxin B Combinations against Multidrug-Resistant Bacteria Associated with Traumatic Wound Infections |
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