Discovery of [11C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases

The measurement of receptor occupancy (RO) using positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS directed therapeutics. We and others have investigated muscarinic acetylcholine receptor 4 (M4) positive allosteric modulators (PAMs) for the treatmen...

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Veröffentlicht in:	Journal of medicinal chemistry 2020-03, Vol.63 (5), p.2411-2425
Hauptverfasser:	Tong, Ling, Li, Wenping, Lo, Michael Man-Chu, Gao, Xiaolei, Wai, Jenny Miu-Chen, Rudd, Michael, Tellers, David, Joshi, Aniket, Zeng, Zhizhen, Miller, Patricia, Salinas, Cristian, Riffel, Kerry, Haley, Hyking, Purcell, Mona, Holahan, Marie, Gantert, Liza, Schubert, Jeffrey W, Jones, Kristen, Mulhearn, James, Egbertson, Melissa, Meng, Zhaoyang, Hanney, Barbara, Gomez, Robert, Harrison, Scott T, McQuade, Paul, Bueters, Tjerk, Uslaner, Jason, Morrow, John, Thomson, Fiona, Kong, Jongrock, Liao, Jing, Selyutin, Oleg, Bao, Jianming, Hastings, Nicholas B, Agrawal, Sony, Magliaro, Brian C, Monsma, Frederick J, Smith, Michelle D, Risso, Stefania, Hesk, David, Hostetler, Eric, Mazzola, Robert
Format:	Artikel
Sprache:	eng
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