Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu 8 Receptor

( S)-3,4-Dicarboxyphenylglycine (DCPG) was first reported in 2001 as a potent orthosteric agonist with high subtype selectivity for the mGlu receptor, but the structural basis for its high selectivity is not well understood. We have solved a cocrystal structure of recombinant human mGlu amino termin...

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Veröffentlicht in:	Journal of medicinal chemistry 2018-11, Vol.61 (22), p.10040-10052
Hauptverfasser:	Chen, Qi, Ho, Joseph D, Ashok, Sheela, Vargas, Michelle C, Wang, Jing, Atwell, Shane, Bures, Mark, Schkeryantz, Jeffery M, Monn, James A, Hao, Junliang
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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