Synthesis, Structure-Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5-HT 4 Receptor Partial Agonists

Alzheimer's disease (AD) is a neurodegenerative disorder that has a higher prevalence and incidence in people older than 60 years. The need for improved AD therapies is unmet as the current therapies are symptomatic with modest efficacy. Partial agonists of the 5-HT receptor (5-HT R) offer both...

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Veröffentlicht in:	Journal of medicinal chemistry 2018-06, Vol.61 (11), p.4993-5008
Hauptverfasser:	Nirogi, Ramakrishna, Mohammed, Abdul Rasheed, Shinde, Anil K, Gagginapally, Shankar Reddy, Kancharla, Durga Malleshwari, Middekadi, Vanaja Reddy, Bogaraju, Narsimha, Ravella, Srinivasa Rao, Singh, Pooja, Birangal, Sumit Raosaheb, Subramanian, Ramkumar, Palacharla, Raghava Choudary, Benade, Vijay, Muddana, Nageswararao, Jayarajan, Pradeep
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Animals Chemistry Techniques, Synthetic Drug Evaluation, Preclinical Humans Male Oxadiazoles - chemical synthesis Oxadiazoles - chemistry Oxadiazoles - pharmacokinetics Oxadiazoles - pharmacology Rats Rats, Wistar Receptors, Serotonin, 5-HT4 - metabolism Serotonin 5-HT4 Receptor Agonists - chemistry Serotonin 5-HT4 Receptor Agonists - pharmacokinetics Serotonin 5-HT4 Receptor Agonists - pharmacology Structure-Activity Relationship
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