Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?

Targeted protein degradation, using bifunctional small molecules (Protacs) to remove specific proteins from within cells, has emerged as a novel drug discovery strategy with the potential to offer therapeutic interventions not achievable with existing approaches. In this Perspective, the brief histo...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2018-01, Vol.61 (2), p.444-452
1. Verfasser:	Churcher, Ian
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Design Drug Discovery Humans Molecular Targeted Therapy - methods Peptides - pharmacology Proteolysis - drug effects Recombinant Proteins - pharmacokinetics Recombinant Proteins - pharmacology Small Molecule Libraries - pharmacology Ubiquitin-Protein Ligases - metabolism Ubiquitination
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!