Amphiphilic Guanidinocalixarenes Inhibit Lipopolysaccharide (LPS)- and Lectin-Stimulated Toll-like Receptor 4 (TLR4) Signaling

We recently reported on the activity of cationic amphiphiles in inhibiting TLR4 activation and subsequent production of inflammatory cytokines in cells and in animal models. Starting from the assumption that opportunely designed cationic amphiphiles can behave as CD14/MD-2 ligands and therefore modu...

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Veröffentlicht in:	Journal of medicinal chemistry 2017-06, Vol.60 (12), p.4882-4892
Hauptverfasser:	Sestito, Stefania E, Facchini, Fabio A, Morbioli, Ilaria, Billod, Jean-Marc, Martin-Santamaria, Sonsoles, Casnati, Alessandro, Sansone, Francesco, Peri, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calixarenes - chemistry Calixarenes - pharmacology Drug Evaluation, Preclinical - methods Guanidine - chemistry Humans Lectins - pharmacology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Ligands Lipopolysaccharide Receptors - metabolism Lipopolysaccharides - pharmacology Lymphocyte Antigen 96 - metabolism Mice, Inbred BALB C Molecular Docking Simulation Molecular Dynamics Simulation Signal Transduction - drug effects Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - metabolism
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