Discovery of 1-((2 R ,4a R ,6 R ,7 R ,7a R )-2-Isopropoxy-2-oxidodihydro-4 H ,6 H -spiro[furo[3,2- d ][1,3,2]dioxaphosphinine-7,2′-oxetan]-6-yl)pyrimidine-2,4(1 H ,3 H )-dione (JNJ-54257099), a 3′-5′-Cyclic Phosphate Ester Prodrug of 2′-Deoxy-2′-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition
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| Veröffentlicht in: | Journal of medicinal chemistry 2016-06, Vol.59 (12), p.5790-5798 |
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| container_end_page | 5798 |
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| container_issue | 12 |
| container_start_page | 5790 |
| container_title | Journal of medicinal chemistry |
| container_volume | 59 |
| creator | Jonckers, Tim H. M. Tahri, Abdellah Vijgen, Leen Berke, Jan Martin Lachau-Durand, Sophie Stoops, Bart Snoeys, Jan Leclercq, Laurent Tambuyzer, Lotke Lin, Tse-I Simmen, Kenny Raboisson, Pierre |
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| doi_str_mv | 10.1021/acs.jmedchem.6b00382 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 2016-06, Vol.59 (12), p.5790-5798 |
| issn | 0022-2623 1520-4804 |
| language | eng |
| recordid | cdi_crossref_primary_10_1021_acs_jmedchem_6b00382 |
| source | ACS Publications |
| title | Discovery of 1-((2 R ,4a R ,6 R ,7 R ,7a R )-2-Isopropoxy-2-oxidodihydro-4 H ,6 H -spiro[furo[3,2- d ][1,3,2]dioxaphosphinine-7,2′-oxetan]-6-yl)pyrimidine-2,4(1 H ,3 H )-dione (JNJ-54257099), a 3′-5′-Cyclic Phosphate Ester Prodrug of 2′-Deoxy-2′-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition |
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