Druglike, 18 F-labeled PET Tracers Targeting Fibroblast Activation Protein

Fibroblast activation protein (FAP) is a very reliable biomarker for tissue remodeling. FAP has so far mainly been studied in oncology, but there is growing interest in the enzyme in other diseases like fibrosis. Recently, FAP-targeting diagnostics and therapeutics have emerged, of which the so-call...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-05, Vol.67 (9), p.7068-7087
Hauptverfasser:	Tanc, Muhammet, Filippi, Nicolò, Van Rymenant, Yentl, Grintsevich, Sergei, Pintelon, Isabel, Verschuuren, Marlies, De Loose, Joni, Verhulst, Emile, Moon, Euy Sung, Cianni, Lorenzo, Stroobants, Sigrid, Augustyns, Koen, Roesch, Frank, De Meester, Ingrid, Elvas, Filipe, Van der Veken, Pieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Endopeptidases - metabolism Female Fluorine Radioisotopes - chemistry Gelatinases - antagonists & inhibitors Gelatinases - metabolism Humans Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism Mice Positron-Emission Tomography - methods Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - chemistry Radiopharmaceuticals - pharmacokinetics Radiopharmaceuticals - pharmacology Serine Endopeptidases - metabolism Tissue Distribution
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