Discovery of Novel Orally Bioavailable Triazoles with Potent and Broad-Spectrum Antifungal Activity In Vitro and In Vivo

In our continuing efforts to discover novel triazoles with improved antifungal activity in vitro and in vivo, a series of 41 novel compounds containing 1,2,3-triazole side chains were designed and synthesized via a click reaction based on our previous work. Most of the compounds showed moderate to e...

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Veröffentlicht in:	Journal of medicinal chemistry 2022-12, Vol.65 (24), p.16665-16678
Hauptverfasser:	Ni, Tingjunhong, Xie, Fei, Hao, Yumeng, Li, Liping, Zhu, Shuo, Wu, Hao, Chi, Xiaochen, Yan, Lan, Jiang, Yuanying, Zhang, Dazhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antifungal Agents - administration & dosage Antifungal Agents - chemistry Antifungal Agents - pharmacokinetics Biological Availability Candida albicans - drug effects Fluconazole - pharmacology Mice Microbial Sensitivity Tests Triazoles - administration & dosage Triazoles - chemistry Triazoles - pharmacokinetics
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