Identification of N- and C-3-Modified Laudanosoline Derivatives as Novel Influenza PA N Endonuclease Inhibitors

Influenza PA inhibitors are of particular importance in current efforts to develop a new generation of antiviral drugs due to the growing emergence of highly pathogenic influenza viruses and the resistance to existing antiviral inhibitors. Herein, we design and synthesize a set of 1,3-cis- -substitu...

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Veröffentlicht in:	Journal of medicinal chemistry 2023-01, Vol.66 (1), p.188-219
Hauptverfasser:	Liao, Yixian, Ye, Yilu, Liu, Mingjian, Liu, Zhihao, Wang, Jinshen, Li, Baixi, Huo, Lijian, Zhuang, Yilian, Chen, Liye, Chen, Jianxin, Gao, Yongfeng, Ning, Xiaoyun, Li, Sumei, Liu, Shuwen, Song, Gaopeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - metabolism Antiviral Agents - pharmacology Endonucleases Humans Influenza, Human Mice Orthomyxoviridae Tetrahydroisoquinolines - pharmacology
Online-Zugang:	Volltext
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