Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT 2A Receptor Agonists

The serotonin 2A receptor (5-HT R) is the mediator of the psychedelic effects of serotonergic psychedelics, which have shown promising results in clinical studies for several neuropsychiatric indications. The 5-HT R is able to signal through the Gα and β-arrestin effector proteins, but it is current...

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Veröffentlicht in:	Journal of medicinal chemistry 2022-09, Vol.65 (18), p.12031-12043
Hauptverfasser:	Poulie, Christian B M, Pottie, Eline, Simon, Icaro A, Harpsøe, Kasper, D'Andrea, Laura, Komarov, Igor V, Gloriam, David E, Jensen, Anders A, Stove, Christophe P, Kristensen, Jesper L
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Arrestins Hallucinogens - pharmacology Lysergic Acid Diethylamide - pharmacology Receptor, Serotonin, 5-HT2A Serotonin Serotonin 5-HT2 Receptor Agonists - pharmacology
Online-Zugang:	Volltext
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