Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo

Cationic antimicrobial peptides (CAMPs) are promising for treatment of multidrug-resistant (MDR) bacteria-caused infections. However, clinical application of CAMPs has been hampered mostly due to their poor proteolytic stability and hemolytic toxicity. Recently, lysine-stapled CAMPs developed by us...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 2022-01, Vol.65 (1), p.579-591
Hauptverfasser:	Hu, Yuchen, Li, Hong, Qu, Rui, He, Tong, Tang, Xiaomin, Chen, Wanyi, Li, Lixian, Bai, Hao, Li, Chao, Wang, Wei, Fu, Gang, Luo, Guangli, Xia, Xuefeng, Zhang, Jinqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimicrobial Cationic Peptides - chemical synthesis Antimicrobial Cationic Peptides - pharmacology Antimicrobial Cationic Peptides - therapeutic use Bacterial Infections - drug therapy Cell Survival - drug effects Drug Resistance, Multiple, Bacterial - drug effects Female HEK293 Cells Hemolysis - drug effects High-Throughput Screening Assays Humans In Vitro Techniques Lysine - chemistry Mice Mice, Inbred C57BL Microbial Sensitivity Tests
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!