Discovery of GLPG2451, a Novel Once Daily Potentiator for the Treatment of Cystic Fibrosis

Cystic fibrosis (CF) is a life-threatening recessive genetic disease caused by mutations in the gene encoding for the cystic fibrosis transmembrane conductance regulator (CFTR). With the discovery of Ivacaftor and Lumacaftor, it has been shown that administration of one or more small molecules can p...

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Veröffentlicht in:	Journal of medicinal chemistry 2021-01, Vol.64 (1), p.343-353
Hauptverfasser:	Van der Plas, Steven E, Kelgtermans, Hans, Mammoliti, Oscar, Menet, Christel, Tricarico, Giovanni, De Blieck, Ann, Joannesse, Caroline, De Munck, Tom, Lambin, Dominique, Cowart, Marlon, Dropsit, Sebastien, Martina, Sebastien L X, Gees, Maarten, Wesse, Anne-Sophie, Conrath, Katja, Andrews, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cystic Fibrosis - drug therapy Cystic Fibrosis Transmembrane Conductance Regulator - genetics Drug Discovery Humans Pyridines - chemistry Pyridines - pharmacokinetics Pyridines - pharmacology Pyridines - therapeutic use Rats
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