Myeloid Differentiation Primary Response Protein 88 (MyD88): The Central Hub of TLR/IL-1R Signaling

Myeloid differentiation primary response protein 88 (MyD88) is a ubiquitously expressed cytoplasmic adaptor protein that plays a central role in the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling pathways. TLR/IL-1R pathways regulate the proliferation and differentiation of ce...

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Veröffentlicht in:	Journal of medicinal chemistry 2020-11, Vol.63 (22), p.13316-13329
Hauptverfasser:	Chen, Lingfeng, Zheng, Lulu, Chen, Pengqin, Liang, Guang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Drug Discovery - methods Drug Discovery - trends Humans Myeloid Differentiation Factor 88 - antagonists & inhibitors Myeloid Differentiation Factor 88 - chemistry Myeloid Differentiation Factor 88 - metabolism Piperazines - chemistry Piperazines - metabolism Piperazines - pharmacology Protein Processing, Post-Translational - drug effects Protein Processing, Post-Translational - physiology Protein Structure, Secondary Protein Structure, Tertiary Receptors, Interleukin-1 - chemistry Receptors, Interleukin-1 - metabolism Signal Transduction - drug effects Signal Transduction - physiology Thiazoles - chemistry Thiazoles - metabolism Thiazoles - pharmacology Toll-Like Receptors - chemistry Toll-Like Receptors - metabolism
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