Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria

Since their discovery over 5 decades ago, quinolone antibiotics have found enormous success as broad spectrum agents that exert their activity through dual inhibition of bacterial DNA gyrase and topoisomerase IV. Increasing rates of resistance, driven largely by target-based mutations in the GyrA/Pa...

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Veröffentlicht in:	Journal of medicinal chemistry 2020-07, Vol.63 (14), p.7773-7816
Hauptverfasser:	Skepper, Colin K, Armstrong, Duncan, Balibar, Carl J, Bauer, Daniel, Bellamacina, Cornelia, Benton, Bret M, Bussiere, Dirksen, De Pascale, Gianfranco, De Vicente, Javier, Dean, Charles R, Dhumale, Bhavesh, Fisher, L. Mark, Fuller, John, Fulsunder, Mangesh, Holder, Lauren M, Hu, Cheng, Kantariya, Bhavin, Lapointe, Guillaume, Leeds, Jennifer A, Li, Xiaolin, Lu, Peichao, Lvov, Anatoli, Ma, Sylvia, Madhavan, Shravanthi, Malekar, Swapnil, McKenney, David, Mergo, Wosenu, Metzger, Louis, Moser, Heinz E, Mutnick, Daniel, Noeske, Jonas, Osborne, Colin, Patel, Ashish, Patel, Darshit, Patel, Tushar, Prajapati, Krunal, Prosen, Katherine R, Reck, Folkert, Richie, Daryl L, Rico, Alice, Sanderson, Mark R, Satasia, Shailesh, Sawyer, William S, Selvarajah, Jogitha, Shah, Nirav, Shanghavi, Kartik, Shu, Wei, Thompson, Katherine V, Traebert, Martin, Vala, Anand, Vala, Lakhan, Veselkov, Dennis A, Vo, Jason, Wang, Michael, Widya, Marcella, Williams, Sarah L, Xu, Yongjin, Yue, Qin, Zang, Richard, Zhou, Bo, Rivkin, Alexey
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - toxicity Binding Sites Cell Line, Tumor DNA Gyrase - metabolism DNA Topoisomerase IV - antagonists & inhibitors DNA Topoisomerase IV - chemistry Drug Resistance, Bacterial - drug effects Fluoroquinolones - chemical synthesis Fluoroquinolones - metabolism Fluoroquinolones - pharmacology Fluoroquinolones - toxicity Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - enzymology Humans Microbial Sensitivity Tests Molecular Structure Structure-Activity Relationship Topoisomerase II Inhibitors - chemical synthesis Topoisomerase II Inhibitors - metabolism Topoisomerase II Inhibitors - pharmacology Topoisomerase II Inhibitors - toxicity
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