Aryl Hydrocarbon Receptor as a Target for Lycopene Preventing DEHP-Induced Spermatogenic Disorders

Di(2-ethylhexyl)phthalate (DEHP) is widely used as a plasticizer to improve product flexibility and workability. Lycopene (LYC) is a natural compound and has promising preventive potentials, especially antireproductive toxicity, but the specific underlying mechanism is yet to be fully defined. Our...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2020-04, Vol.68 (15), p.4355-4366
Hauptverfasser:	Zhao, Yi, Lin, Jia, Talukder, Milton, Zhu, Shi-Yong, Li, Mu-Zi, Wang, Hao-Ran, Li, Jin-Long
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diethylhexyl Phthalate - toxicity DNA Damage - drug effects Humans Infertility, Male - drug therapy Infertility, Male - etiology Infertility, Male - metabolism Infertility, Male - physiopathology Lycopene - administration & dosage Male Mice Mice, Inbred ICR Mitochondria - drug effects Mitochondria - metabolism Plasticizers - toxicity Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Sperm Motility - drug effects Spermatogenesis - drug effects Spermatozoa - cytology Spermatozoa - drug effects Spermatozoa - metabolism
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