Ginger Extract-Loaded Solid Dispersion System with Enhanced Oral Absorption and Antihypothermic Action
The aim of this study is to enhance the antihypothermic action of ginger extract (GE) employing a solid dispersion (SD) approach. The prepared SD of GE (GE/SD) was characterized in terms of physicochemical and pharmacokinetic properties. The antihypothermic action of GE samples was evaluated in a ra...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2017-02, Vol.65 (7), p.1365-1370 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Sato, Hideyuki Ogino, Mizuki Yakushiji, Keisuke Suzuki, Hiroki Shiokawa, Ken-ichi Kikuchi, Hiroshi Seto, Yoshiki Onoue, Satomi |
| description | The aim of this study is to enhance the antihypothermic action of ginger extract (GE) employing a solid dispersion (SD) approach. The prepared SD of GE (GE/SD) was characterized in terms of physicochemical and pharmacokinetic properties. The antihypothermic action of GE samples was evaluated in a rat model of hypothermia. GE/SD exhibited improved dissolution behavior of the major active ingredients in GE, 6-gingerol (6G) and 8-gingerol (8G), with levels of dissolution 12- and 31-fold higher than that of GE, respectively. Even after storage under accelerated conditions, limited degradations of 6G and 8G were observed in GE/SD, although 6G and 8G were slightly degraded in GE. After oral administration of GE (300 mg/kg) and GE/SD (100 mg of GE/kg), the relative bioavailabilities of 6G and 8G in GE/SD were 5.0- and 5.8-fold higher than those in GE, respectively. Orally administered GE/SD (30 mg of GE/kg) inhibited ethanol-evoked hypothermia because of improved oral absorption of 6G and 8G. From these observations, the SD approach might be efficacious for enhancing the nutraceutical potentials of GE. |
| doi_str_mv | 10.1021/acs.jafc.6b04740 |
| format | Article |
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The prepared SD of GE (GE/SD) was characterized in terms of physicochemical and pharmacokinetic properties. The antihypothermic action of GE samples was evaluated in a rat model of hypothermia. GE/SD exhibited improved dissolution behavior of the major active ingredients in GE, 6-gingerol (6G) and 8-gingerol (8G), with levels of dissolution 12- and 31-fold higher than that of GE, respectively. Even after storage under accelerated conditions, limited degradations of 6G and 8G were observed in GE/SD, although 6G and 8G were slightly degraded in GE. After oral administration of GE (300 mg/kg) and GE/SD (100 mg of GE/kg), the relative bioavailabilities of 6G and 8G in GE/SD were 5.0- and 5.8-fold higher than those in GE, respectively. Orally administered GE/SD (30 mg of GE/kg) inhibited ethanol-evoked hypothermia because of improved oral absorption of 6G and 8G. From these observations, the SD approach might be efficacious for enhancing the nutraceutical potentials of GE.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/acs.jafc.6b04740</identifier><identifier>PMID: 28132501</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Biological Availability ; Body Temperature ; Catechols - administration & dosage ; Catechols - chemistry ; Chemistry, Pharmaceutical ; Drug Stability ; Fatty Alcohols - administration & dosage ; Fatty Alcohols - chemistry ; Humans ; Hypothermia - drug therapy ; Male ; Plant Extracts - administration & dosage ; Plant Extracts - chemistry ; Rats ; Solubility ; Zingiber officinale - chemistry</subject><ispartof>Journal of agricultural and food chemistry, 2017-02, Vol.65 (7), p.1365-1370</ispartof><rights>Copyright © 2017 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a336t-5e51eb609c161eee517810ea4cc3fb7723ff265a65d4e7ad6b91a25736462cfc3</citedby><cites>FETCH-LOGICAL-a336t-5e51eb609c161eee517810ea4cc3fb7723ff265a65d4e7ad6b91a25736462cfc3</cites><orcidid>0000-0002-5155-2003</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.jafc.6b04740$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.jafc.6b04740$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28132501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, Hideyuki</creatorcontrib><creatorcontrib>Ogino, Mizuki</creatorcontrib><creatorcontrib>Yakushiji, Keisuke</creatorcontrib><creatorcontrib>Suzuki, Hiroki</creatorcontrib><creatorcontrib>Shiokawa, Ken-ichi</creatorcontrib><creatorcontrib>Kikuchi, Hiroshi</creatorcontrib><creatorcontrib>Seto, Yoshiki</creatorcontrib><creatorcontrib>Onoue, Satomi</creatorcontrib><title>Ginger Extract-Loaded Solid Dispersion System with Enhanced Oral Absorption and Antihypothermic Action</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>The aim of this study is to enhance the antihypothermic action of ginger extract (GE) employing a solid dispersion (SD) approach. The prepared SD of GE (GE/SD) was characterized in terms of physicochemical and pharmacokinetic properties. The antihypothermic action of GE samples was evaluated in a rat model of hypothermia. GE/SD exhibited improved dissolution behavior of the major active ingredients in GE, 6-gingerol (6G) and 8-gingerol (8G), with levels of dissolution 12- and 31-fold higher than that of GE, respectively. Even after storage under accelerated conditions, limited degradations of 6G and 8G were observed in GE/SD, although 6G and 8G were slightly degraded in GE. After oral administration of GE (300 mg/kg) and GE/SD (100 mg of GE/kg), the relative bioavailabilities of 6G and 8G in GE/SD were 5.0- and 5.8-fold higher than those in GE, respectively. Orally administered GE/SD (30 mg of GE/kg) inhibited ethanol-evoked hypothermia because of improved oral absorption of 6G and 8G. From these observations, the SD approach might be efficacious for enhancing the nutraceutical potentials of GE.</description><subject>Animals</subject><subject>Biological Availability</subject><subject>Body Temperature</subject><subject>Catechols - administration & dosage</subject><subject>Catechols - chemistry</subject><subject>Chemistry, Pharmaceutical</subject><subject>Drug Stability</subject><subject>Fatty Alcohols - administration & dosage</subject><subject>Fatty Alcohols - chemistry</subject><subject>Humans</subject><subject>Hypothermia - drug therapy</subject><subject>Male</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - chemistry</subject><subject>Rats</subject><subject>Solubility</subject><subject>Zingiber officinale - chemistry</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtOwzAQRS0EouWxZ4X8AaTMOLGTLqtSClKlLgrryHFs4qp5yHYF_XsSWtixGo3m3CvNIeQOYYLA8FEqP9lKoyaigCRN4IyMkTOIOGJ2TsbQM1HGBY7IlfdbAMh4CpdkxDKMGQccE7O0zYd2dPEVnFQhWrWy1CXdtDtb0ifrO-28bRu6Ofiga_ppQ0UXTSUb1VNrJ3d0VvjWdWGAZFPSWRNsdejaUGlXW0VnajjdkAsjd17fnuY1eX9evM1fotV6-TqfrSIZxyJEXHPUhYCpQoFa91uaIWiZKBWbIk1ZbAwTXApeJjqVpSimKBlPY5EIpoyKrwkce5VrvXfa5J2ztXSHHCEflOW9snxQlp-U9ZH7Y6TbF7Uu_wK_jnrg4Qj8RNu9a_oP_u_7BqwzeQc</recordid><startdate>20170222</startdate><enddate>20170222</enddate><creator>Sato, Hideyuki</creator><creator>Ogino, Mizuki</creator><creator>Yakushiji, Keisuke</creator><creator>Suzuki, Hiroki</creator><creator>Shiokawa, Ken-ichi</creator><creator>Kikuchi, Hiroshi</creator><creator>Seto, Yoshiki</creator><creator>Onoue, Satomi</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-5155-2003</orcidid></search><sort><creationdate>20170222</creationdate><title>Ginger Extract-Loaded Solid Dispersion System with Enhanced Oral Absorption and Antihypothermic Action</title><author>Sato, Hideyuki ; Ogino, Mizuki ; Yakushiji, Keisuke ; Suzuki, Hiroki ; Shiokawa, Ken-ichi ; Kikuchi, Hiroshi ; Seto, Yoshiki ; Onoue, Satomi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a336t-5e51eb609c161eee517810ea4cc3fb7723ff265a65d4e7ad6b91a25736462cfc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Biological Availability</topic><topic>Body Temperature</topic><topic>Catechols - administration & dosage</topic><topic>Catechols - chemistry</topic><topic>Chemistry, Pharmaceutical</topic><topic>Drug Stability</topic><topic>Fatty Alcohols - administration & dosage</topic><topic>Fatty Alcohols - chemistry</topic><topic>Humans</topic><topic>Hypothermia - drug therapy</topic><topic>Male</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - chemistry</topic><topic>Rats</topic><topic>Solubility</topic><topic>Zingiber officinale - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, Hideyuki</creatorcontrib><creatorcontrib>Ogino, Mizuki</creatorcontrib><creatorcontrib>Yakushiji, Keisuke</creatorcontrib><creatorcontrib>Suzuki, Hiroki</creatorcontrib><creatorcontrib>Shiokawa, Ken-ichi</creatorcontrib><creatorcontrib>Kikuchi, Hiroshi</creatorcontrib><creatorcontrib>Seto, Yoshiki</creatorcontrib><creatorcontrib>Onoue, Satomi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Hideyuki</au><au>Ogino, Mizuki</au><au>Yakushiji, Keisuke</au><au>Suzuki, Hiroki</au><au>Shiokawa, Ken-ichi</au><au>Kikuchi, Hiroshi</au><au>Seto, Yoshiki</au><au>Onoue, Satomi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ginger Extract-Loaded Solid Dispersion System with Enhanced Oral Absorption and Antihypothermic Action</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2017-02-22</date><risdate>2017</risdate><volume>65</volume><issue>7</issue><spage>1365</spage><epage>1370</epage><pages>1365-1370</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>The aim of this study is to enhance the antihypothermic action of ginger extract (GE) employing a solid dispersion (SD) approach. The prepared SD of GE (GE/SD) was characterized in terms of physicochemical and pharmacokinetic properties. The antihypothermic action of GE samples was evaluated in a rat model of hypothermia. GE/SD exhibited improved dissolution behavior of the major active ingredients in GE, 6-gingerol (6G) and 8-gingerol (8G), with levels of dissolution 12- and 31-fold higher than that of GE, respectively. Even after storage under accelerated conditions, limited degradations of 6G and 8G were observed in GE/SD, although 6G and 8G were slightly degraded in GE. After oral administration of GE (300 mg/kg) and GE/SD (100 mg of GE/kg), the relative bioavailabilities of 6G and 8G in GE/SD were 5.0- and 5.8-fold higher than those in GE, respectively. Orally administered GE/SD (30 mg of GE/kg) inhibited ethanol-evoked hypothermia because of improved oral absorption of 6G and 8G. From these observations, the SD approach might be efficacious for enhancing the nutraceutical potentials of GE.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>28132501</pmid><doi>10.1021/acs.jafc.6b04740</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5155-2003</orcidid></addata></record> |
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| source | ACS Publications; MEDLINE |
| subjects | Animals Biological Availability Body Temperature Catechols - administration & dosage Catechols - chemistry Chemistry, Pharmaceutical Drug Stability Fatty Alcohols - administration & dosage Fatty Alcohols - chemistry Humans Hypothermia - drug therapy Male Plant Extracts - administration & dosage Plant Extracts - chemistry Rats Solubility Zingiber officinale - chemistry |
| title | Ginger Extract-Loaded Solid Dispersion System with Enhanced Oral Absorption and Antihypothermic Action |
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