Sodium Dodecyl Sulfate-Dependent Disassembly and Reassembly of Soybean Lipophilic Protein Nanoparticles: An Environmentally Friendly Nanocarrier for Resveratrol

The development of protein-based nanocarriers to improve the water solubility, stability, and bioavailability of hydrophobic or poorly soluble bioactive molecules has attracted increasing interest in the food and pharmaceutical industries. In this study, a network-like nanostructure of soybean lipop...

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Veröffentlicht in:Journal of agricultural and food chemistry 2022-02, Vol.70 (5), p.1640-1651
Hauptverfasser: Zhong, Mingming, Sun, Yufan, Sun, Yuanda, Song, Hanyu, Zhang, Shuang, Qi, Baokun, Li, Yang
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container_end_page 1651
container_issue 5
container_start_page 1640
container_title Journal of agricultural and food chemistry
container_volume 70
creator Zhong, Mingming
Sun, Yufan
Sun, Yuanda
Song, Hanyu
Zhang, Shuang
Qi, Baokun
Li, Yang
description The development of protein-based nanocarriers to improve the water solubility, stability, and bioavailability of hydrophobic or poorly soluble bioactive molecules has attracted increasing interest in the food and pharmaceutical industries. In this study, a network-like nanostructure of soybean lipophilic protein (LP) was obtained through sodium dodecyl sulfate (SDS)-dependent decomposition and recombination. This nanostructure served as an excellent nanocarrier for resveratrol (Res), a poorly soluble biologically active molecule. The structure of LP gradually decomposed into its independent subunits at SDS concentrations ≤5% (w/v). After the removal of SDS, the dissociated subunits partially reassembled into a fibrous network-like nanostructure in which the Res molecules were encapsulated, and they preferentially interacted with the hydrophobic subunits (α and α′ subunits and the 24 kDa subunit) of the protein. This system exhibited a high encapsulation efficiency (95.93%), high water solubility (85.29%), extraordinary oxidation resistance (DPPH radical scavenging activity of 67.1%), and improved Res digestibility (78.7%).
doi_str_mv 10.1021/acs.jafc.1c06622
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Agric. Food Chem</addtitle><date>2022-02-09</date><risdate>2022</risdate><volume>70</volume><issue>5</issue><spage>1640</spage><epage>1651</epage><pages>1640-1651</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>The development of protein-based nanocarriers to improve the water solubility, stability, and bioavailability of hydrophobic or poorly soluble bioactive molecules has attracted increasing interest in the food and pharmaceutical industries. In this study, a network-like nanostructure of soybean lipophilic protein (LP) was obtained through sodium dodecyl sulfate (SDS)-dependent decomposition and recombination. This nanostructure served as an excellent nanocarrier for resveratrol (Res), a poorly soluble biologically active molecule. The structure of LP gradually decomposed into its independent subunits at SDS concentrations ≤5% (w/v). 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source MEDLINE; ACS_美国化学学会期刊(与NSTL共建)
subjects Food and Beverage Chemistry/Biochemistry
Glycine max
Nanoparticles
Resveratrol
Sodium Dodecyl Sulfate
Solubility
Soybean Proteins
title Sodium Dodecyl Sulfate-Dependent Disassembly and Reassembly of Soybean Lipophilic Protein Nanoparticles: An Environmentally Friendly Nanocarrier for Resveratrol
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