Anti-Inflammatory and Intestinal Microbiota Modulation Properties of Jinxiang Garlic (Allium sativum L.) Polysaccharides toward Dextran Sodium Sulfate-Induced Colitis
Garlic polysaccharides are great potential agents because of their anti-inflammation, antioxidation, and immunomodulation properties. However, few studies have reported their anti-inflammatory effects on improving the colon system and corresponding intestinal microbiota. Herein, a water-soluble garl...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2020-11, Vol.68 (44), p.12295-12309 |
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| creator | Shao, Xin Sun, Chongzhen Tang, Xin Zhang, Xiaosa Han, Duo Liang, Shan Qu, Rong Hui, Xiaodan Shan, Yangwei Hu, Linhui Fang, Heng Zhang, Huidan Wu, Xiyang Chen, Chunbo |
| description | Garlic polysaccharides are great potential agents because of their anti-inflammation, antioxidation, and immunomodulation properties. However, few studies have reported their anti-inflammatory effects on improving the colon system and corresponding intestinal microbiota. Herein, a water-soluble garlic polysaccharide (WSGP) was extracted from Jinxiang garlic to evaluate its effects on ameliorating dextran sulfate sodium (DSS)-induced colitis in a mouse model. The results showed that (1) after administration of the WSGP (200 or 400 mg/kg/day), the feed intake, body weight, and colon length of colitic mice were increased, while the disease activity index and the histological score of colitic mice were decreased; (2) the WSGP reduced the colonic tissue damage and inhibited the expression of inflammatory factors (interleukin 6, interleukin 1 beta , and tumor necrosis factor alpha); and (3) the WSGP enhanced the production of short-chain fatty acids and improved the composition of intestinal microbiota. The key microorganisms, including Muribaculaceae, Lachnospiraceae, Lachnospiraceae_NK4A136_group, Mucispirillum, Helicobacter, Ruminococcus_1, and Ruminiclostridium_5, were identified to be associated with inflammatory bowel diseases. Taken together, this study proved that WSGP supplementation could alleviate DSS-induced colitis by improving mucosal barriers, blocking proinflammatory cytokines, and modulating gut microbiota. |
| doi_str_mv | 10.1021/acs.jafc.0c04773 |
| format | Article |
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Polysaccharides toward Dextran Sodium Sulfate-Induced Colitis</title><source>MEDLINE</source><source>American Chemical Society Journals</source><creator>Shao, Xin ; Sun, Chongzhen ; Tang, Xin ; Zhang, Xiaosa ; Han, Duo ; Liang, Shan ; Qu, Rong ; Hui, Xiaodan ; Shan, Yangwei ; Hu, Linhui ; Fang, Heng ; Zhang, Huidan ; Wu, Xiyang ; Chen, Chunbo</creator><creatorcontrib>Shao, Xin ; Sun, Chongzhen ; Tang, Xin ; Zhang, Xiaosa ; Han, Duo ; Liang, Shan ; Qu, Rong ; Hui, Xiaodan ; Shan, Yangwei ; Hu, Linhui ; Fang, Heng ; Zhang, Huidan ; Wu, Xiyang ; Chen, Chunbo</creatorcontrib><description>Garlic polysaccharides are great potential agents because of their anti-inflammation, antioxidation, and immunomodulation properties. However, few studies have reported their anti-inflammatory effects on improving the colon system and corresponding intestinal microbiota. Herein, a water-soluble garlic polysaccharide (WSGP) was extracted from Jinxiang garlic to evaluate its effects on ameliorating dextran sulfate sodium (DSS)-induced colitis in a mouse model. The results showed that (1) after administration of the WSGP (200 or 400 mg/kg/day), the feed intake, body weight, and colon length of colitic mice were increased, while the disease activity index and the histological score of colitic mice were decreased; (2) the WSGP reduced the colonic tissue damage and inhibited the expression of inflammatory factors (interleukin 6, interleukin 1 beta , and tumor necrosis factor alpha); and (3) the WSGP enhanced the production of short-chain fatty acids and improved the composition of intestinal microbiota. The key microorganisms, including Muribaculaceae, Lachnospiraceae, Lachnospiraceae_NK4A136_group, Mucispirillum, Helicobacter, Ruminococcus_1, and Ruminiclostridium_5, were identified to be associated with inflammatory bowel diseases. Taken together, this study proved that WSGP supplementation could alleviate DSS-induced colitis by improving mucosal barriers, blocking proinflammatory cytokines, and modulating gut microbiota.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/acs.jafc.0c04773</identifier><identifier>PMID: 33095019</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - chemistry ; Bacteria - classification ; Bacteria - drug effects ; Bacteria - genetics ; Bacteria - isolation & purification ; Bioactive Constituents, Metabolites, and Functions ; Colitis - chemically induced ; Colitis - drug therapy ; Colitis - immunology ; Colitis - microbiology ; Dextran Sulfate - adverse effects ; Disease Models, Animal ; Garlic - chemistry ; Gastrointestinal Microbiome - drug effects ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Plant Extracts - administration & dosage ; Plant Extracts - chemistry ; Polysaccharides - administration & dosage ; Polysaccharides - chemistry</subject><ispartof>Journal of agricultural and food chemistry, 2020-11, Vol.68 (44), p.12295-12309</ispartof><rights>2020 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a336t-92c961e4431d083b017699ffc04349f1121b95308f3dd0b45c850bbb7ed6e2f43</citedby><cites>FETCH-LOGICAL-a336t-92c961e4431d083b017699ffc04349f1121b95308f3dd0b45c850bbb7ed6e2f43</cites><orcidid>0000-0002-0255-8249 ; 0000-0001-5662-497X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.jafc.0c04773$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.jafc.0c04773$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33095019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shao, Xin</creatorcontrib><creatorcontrib>Sun, Chongzhen</creatorcontrib><creatorcontrib>Tang, Xin</creatorcontrib><creatorcontrib>Zhang, Xiaosa</creatorcontrib><creatorcontrib>Han, Duo</creatorcontrib><creatorcontrib>Liang, Shan</creatorcontrib><creatorcontrib>Qu, Rong</creatorcontrib><creatorcontrib>Hui, Xiaodan</creatorcontrib><creatorcontrib>Shan, Yangwei</creatorcontrib><creatorcontrib>Hu, Linhui</creatorcontrib><creatorcontrib>Fang, Heng</creatorcontrib><creatorcontrib>Zhang, Huidan</creatorcontrib><creatorcontrib>Wu, Xiyang</creatorcontrib><creatorcontrib>Chen, Chunbo</creatorcontrib><title>Anti-Inflammatory and Intestinal Microbiota Modulation Properties of Jinxiang Garlic (Allium sativum L.) Polysaccharides toward Dextran Sodium Sulfate-Induced Colitis</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Garlic polysaccharides are great potential agents because of their anti-inflammation, antioxidation, and immunomodulation properties. However, few studies have reported their anti-inflammatory effects on improving the colon system and corresponding intestinal microbiota. Herein, a water-soluble garlic polysaccharide (WSGP) was extracted from Jinxiang garlic to evaluate its effects on ameliorating dextran sulfate sodium (DSS)-induced colitis in a mouse model. The results showed that (1) after administration of the WSGP (200 or 400 mg/kg/day), the feed intake, body weight, and colon length of colitic mice were increased, while the disease activity index and the histological score of colitic mice were decreased; (2) the WSGP reduced the colonic tissue damage and inhibited the expression of inflammatory factors (interleukin 6, interleukin 1 beta , and tumor necrosis factor alpha); and (3) the WSGP enhanced the production of short-chain fatty acids and improved the composition of intestinal microbiota. The key microorganisms, including Muribaculaceae, Lachnospiraceae, Lachnospiraceae_NK4A136_group, Mucispirillum, Helicobacter, Ruminococcus_1, and Ruminiclostridium_5, were identified to be associated with inflammatory bowel diseases. Taken together, this study proved that WSGP supplementation could alleviate DSS-induced colitis by improving mucosal barriers, blocking proinflammatory cytokines, and modulating gut microbiota.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Bacteria - classification</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - genetics</subject><subject>Bacteria - isolation & purification</subject><subject>Bioactive Constituents, Metabolites, and Functions</subject><subject>Colitis - chemically induced</subject><subject>Colitis - drug therapy</subject><subject>Colitis - immunology</subject><subject>Colitis - microbiology</subject><subject>Dextran Sulfate - adverse effects</subject><subject>Disease Models, Animal</subject><subject>Garlic - chemistry</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - chemistry</subject><subject>Polysaccharides - administration & dosage</subject><subject>Polysaccharides - chemistry</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtvEzEUhS1ERUNhzwp5CVInvR7PcxkFWoJStVJhPbrjB7jy2JHtKc0f4nfikMKuq7M539G9HyHvGCwZlOwCRVzeoxZLEFC1LX9BFqwuoagZ616SBeRO0dUNOyWvY7wHgK5u4RU55Rz6Gli_IL9XLpli47TFacLkw56ik3TjkorJOLT02ojgR-MT0msvZ4vJeEdvg9-pkIyK1Gv61bhHg-4HvcJgjaAfVtaaeaIxlx9ybpcf6a23-4hC_MRgZMaS_4VB0k_qMQV09M7LA3E3W41J5YvkLJSka29NMvENOdFoo3r7lGfk--Xnb-svxfbmarNebQvkvElFX4q-YaqqOJPQ8RFY2_S91tkOr3rNWMnGvubQaS4ljFUtuhrGcWyVbFSpK35G4Libf44xKD3sgpkw7AcGw0H5kJUPB-XDk_KMvD8iu3mclPwP_HOcC-fHwl_UzyFbjc_v_QF_85Au</recordid><startdate>20201104</startdate><enddate>20201104</enddate><creator>Shao, Xin</creator><creator>Sun, Chongzhen</creator><creator>Tang, Xin</creator><creator>Zhang, Xiaosa</creator><creator>Han, Duo</creator><creator>Liang, Shan</creator><creator>Qu, Rong</creator><creator>Hui, Xiaodan</creator><creator>Shan, Yangwei</creator><creator>Hu, Linhui</creator><creator>Fang, Heng</creator><creator>Zhang, Huidan</creator><creator>Wu, Xiyang</creator><creator>Chen, Chunbo</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-0255-8249</orcidid><orcidid>https://orcid.org/0000-0001-5662-497X</orcidid></search><sort><creationdate>20201104</creationdate><title>Anti-Inflammatory and Intestinal Microbiota Modulation Properties of Jinxiang Garlic (Allium sativum L.) Polysaccharides toward Dextran Sodium Sulfate-Induced Colitis</title><author>Shao, Xin ; Sun, Chongzhen ; Tang, Xin ; Zhang, Xiaosa ; Han, Duo ; Liang, Shan ; Qu, Rong ; Hui, Xiaodan ; Shan, Yangwei ; Hu, Linhui ; Fang, Heng ; Zhang, Huidan ; Wu, Xiyang ; Chen, Chunbo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a336t-92c961e4431d083b017699ffc04349f1121b95308f3dd0b45c850bbb7ed6e2f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Bacteria - classification</topic><topic>Bacteria - drug effects</topic><topic>Bacteria - genetics</topic><topic>Bacteria - isolation & purification</topic><topic>Bioactive Constituents, Metabolites, and Functions</topic><topic>Colitis - chemically induced</topic><topic>Colitis - drug therapy</topic><topic>Colitis - immunology</topic><topic>Colitis - microbiology</topic><topic>Dextran Sulfate - adverse effects</topic><topic>Disease Models, Animal</topic><topic>Garlic - chemistry</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - chemistry</topic><topic>Polysaccharides - administration & dosage</topic><topic>Polysaccharides - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shao, Xin</creatorcontrib><creatorcontrib>Sun, Chongzhen</creatorcontrib><creatorcontrib>Tang, Xin</creatorcontrib><creatorcontrib>Zhang, Xiaosa</creatorcontrib><creatorcontrib>Han, Duo</creatorcontrib><creatorcontrib>Liang, Shan</creatorcontrib><creatorcontrib>Qu, Rong</creatorcontrib><creatorcontrib>Hui, Xiaodan</creatorcontrib><creatorcontrib>Shan, Yangwei</creatorcontrib><creatorcontrib>Hu, Linhui</creatorcontrib><creatorcontrib>Fang, Heng</creatorcontrib><creatorcontrib>Zhang, Huidan</creatorcontrib><creatorcontrib>Wu, Xiyang</creatorcontrib><creatorcontrib>Chen, Chunbo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shao, Xin</au><au>Sun, Chongzhen</au><au>Tang, Xin</au><au>Zhang, Xiaosa</au><au>Han, Duo</au><au>Liang, Shan</au><au>Qu, Rong</au><au>Hui, Xiaodan</au><au>Shan, Yangwei</au><au>Hu, Linhui</au><au>Fang, Heng</au><au>Zhang, Huidan</au><au>Wu, Xiyang</au><au>Chen, Chunbo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Inflammatory and Intestinal Microbiota Modulation Properties of Jinxiang Garlic (Allium sativum L.) Polysaccharides toward Dextran Sodium Sulfate-Induced Colitis</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2020-11-04</date><risdate>2020</risdate><volume>68</volume><issue>44</issue><spage>12295</spage><epage>12309</epage><pages>12295-12309</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>Garlic polysaccharides are great potential agents because of their anti-inflammation, antioxidation, and immunomodulation properties. However, few studies have reported their anti-inflammatory effects on improving the colon system and corresponding intestinal microbiota. Herein, a water-soluble garlic polysaccharide (WSGP) was extracted from Jinxiang garlic to evaluate its effects on ameliorating dextran sulfate sodium (DSS)-induced colitis in a mouse model. The results showed that (1) after administration of the WSGP (200 or 400 mg/kg/day), the feed intake, body weight, and colon length of colitic mice were increased, while the disease activity index and the histological score of colitic mice were decreased; (2) the WSGP reduced the colonic tissue damage and inhibited the expression of inflammatory factors (interleukin 6, interleukin 1 beta , and tumor necrosis factor alpha); and (3) the WSGP enhanced the production of short-chain fatty acids and improved the composition of intestinal microbiota. The key microorganisms, including Muribaculaceae, Lachnospiraceae, Lachnospiraceae_NK4A136_group, Mucispirillum, Helicobacter, Ruminococcus_1, and Ruminiclostridium_5, were identified to be associated with inflammatory bowel diseases. Taken together, this study proved that WSGP supplementation could alleviate DSS-induced colitis by improving mucosal barriers, blocking proinflammatory cytokines, and modulating gut microbiota.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>33095019</pmid><doi>10.1021/acs.jafc.0c04773</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-0255-8249</orcidid><orcidid>https://orcid.org/0000-0001-5662-497X</orcidid></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Bacteria - classification Bacteria - drug effects Bacteria - genetics Bacteria - isolation & purification Bioactive Constituents, Metabolites, and Functions Colitis - chemically induced Colitis - drug therapy Colitis - immunology Colitis - microbiology Dextran Sulfate - adverse effects Disease Models, Animal Garlic - chemistry Gastrointestinal Microbiome - drug effects Humans Male Mice Mice, Inbred C57BL Plant Extracts - administration & dosage Plant Extracts - chemistry Polysaccharides - administration & dosage Polysaccharides - chemistry |
| title | Anti-Inflammatory and Intestinal Microbiota Modulation Properties of Jinxiang Garlic (Allium sativum L.) Polysaccharides toward Dextran Sodium Sulfate-Induced Colitis |
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