Formation of Bulky DNA Adducts by Non-Enzymatic Production of 1,2-Naphthoquinone-Epoxide from 1,2-Naphthoquinone under Physiological Conditions

Quinones may be formed metabolically or abiotically from environmental pollutants and polycyclic aromatic hydrocarbons (PAHs); many are recognized as toxicological intermediates that cause a variety of deleterious cellular effects including mutagenicity. The PAH-o-quinone, 1,2-naphthoquinone (1,2-NQ...

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Veröffentlicht in:	Chemical research in toxicology 2019-09, Vol.32 (9), p.1760-1771
Hauptverfasser:	Matsui, Takuya, Yamada, Naohito, Kuno, Hideyuki, Kanaly, Robert A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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