Thalidomide and Its Analogs Differentially Target Fibroblast Growth Factor Receptors: Thalidomide Suppresses FGFR Gene Expression while Pomalidomide Dampens FGFR2 Activity

Thalidomide is an infamous teratogen and it is continuously being explored for its anticancer properties. Fibroblast growth factor receptors (FGFRs) are implicated in embryo development and cancer pathophysiology. With striking similarities observed between FGFR implicated conditions and thalidomide...

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Veröffentlicht in:	Chemical research in toxicology 2019-04, Vol.32 (4), p.589-602
Hauptverfasser:	Sundaresan, Lakshmikirupa, Kumar, Pavitra, Manivannan, Jeganathan, Balaguru, Uma Maheswari, Kasiviswanathan, Dharanibalan, Veeriah, Vimal, Anishetty, Sharmila, Chatterjee, Suvro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival - drug effects Cells, Cultured Chick Embryo Chickens Dose-Response Relationship, Drug Gene Expression Profiling Humans Molecular Docking Simulation Molecular Structure Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Receptors, Fibroblast Growth Factor - antagonists & inhibitors Receptors, Fibroblast Growth Factor - genetics Receptors, Fibroblast Growth Factor - metabolism Structure-Activity Relationship Thalidomide - analogs & derivatives Thalidomide - chemistry Thalidomide - pharmacology
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