The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity

Cadmium (Cd) is an environmental electrophile that modifies protein nucleophiles, thereby modulating cellular signaling and toxicity. While reactive persulfides/polysulfides exhibit relatively high nucleophilic properties, their roles in the altered gene expression and toxicity caused by Cd remain u...

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Veröffentlicht in:	Chemical research in toxicology 2017-12, Vol.30 (12), p.2209-2217
Hauptverfasser:	Akiyama, Masahiro, Shinkai, Yasuhiro, Unoki, Takamitsu, Shim, Ilseob, Ishii, Isao, Kumagai, Yoshito
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cadmium - chemistry Cadmium - toxicity Cell Survival - drug effects Cystathionine gamma-Lyase - deficiency Cystathionine gamma-Lyase - metabolism Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - pathology Male Mice Mice, Inbred C57BL Mice, Knockout Sulfides - chemistry Sulfides - pharmacology
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