In Vivo Metabolism of Aristolochic Acid I and II in Rats Is Influenced by Their Coexposure

The plant extract aristolochic acid (AA), containing aristolochic acid I (AAI) and II (AAII) as major components, causes aristolochic acid nephropathy and Balkan endemic nephropathy, unique renal diseases associated with upper urothelial cancer. Differences in the metabolic activation and detoxifica...

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Veröffentlicht in:	Chemical research in toxicology 2020-11, Vol.33 (11), p.2804-2818
Hauptverfasser:	Dedı́ková, Alena, Bárta, František, Martínek, Václav, Kotalík, Kevin, Dušková, Šárka, Mráz, Jaroslav, Arlt, Volker Manfred, Stiborová, Marie, Hodek, Petr
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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