Ionic Hydrogel Based on Chitosan Cross-Linked with 6‑Phosphogluconic Trisodium Salt as a Drug Delivery System
In this work, 6-phosphogluconic trisodium salt (6-PG–Na+) is introduced as a new aqueous and nontoxic cross-linking agent to obtain ionic hydrogels. Here, it is shown the formation of hydrogels based on chitosan cross-linked with 6-PG–Na+. This formulation is obtained by ionic interaction of cationi...
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| Veröffentlicht in: | Biomacromolecules 2018-04, Vol.19 (4), p.1294-1304 |
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| container_title | Biomacromolecules |
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| creator | Martínez-Martínez, Mayte Rodríguez-Berna, Guillermo Gonzalez-Alvarez, Isabel Hernández, M Corma, Avelino Bermejo, Marival Merino, Virginia Gonzalez-Alvarez, Marta |
| description | In this work, 6-phosphogluconic trisodium salt (6-PG–Na+) is introduced as a new aqueous and nontoxic cross-linking agent to obtain ionic hydrogels. Here, it is shown the formation of hydrogels based on chitosan cross-linked with 6-PG–Na+. This formulation is obtained by ionic interaction of cationic groups of polymer with anionic groups of the cross-linker. These hydrogels are nontoxic, do not cause dermal irritation, are easy to extend, and have an adequate adhesion force to be applied as polymeric film over the skin. This formulation exhibits a first order release kinetic and can be applied as drug vehicle for topical administration or as wound dressing for wound healing. The primary goal of this communication is to report the identification and utility of 6-phosphogluconic trisodium salt (6-PG–Na+) as a nontoxic cross-linker applicable for cationic polymers. |
| doi_str_mv | 10.1021/acs.biomac.8b00108 |
| format | Article |
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The primary goal of this communication is to report the identification and utility of 6-phosphogluconic trisodium salt (6-PG–Na+) as a nontoxic cross-linker applicable for cationic polymers.</description><subject>Administration, Topical</subject><subject>Chitosan - administration & dosage</subject><subject>Chitosan - chemistry</subject><subject>Cross-Linking Reagents - chemistry</subject><subject>Drug Delivery Systems</subject><subject>Gluconates - administration & dosage</subject><subject>Gluconates - chemistry</subject><subject>Humans</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry</subject><subject>Kinetics</subject><subject>Polymers - chemistry</subject><subject>Sodium</subject><subject>Wound Closure Techniques</subject><subject>Wound Healing - drug effects</subject><issn>1525-7797</issn><issn>1526-4602</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFOwzAQRS0EoqVwARbIF0iw48ROltACrVQJpJZ1ZDtO45LElZ2AsuMKXJGTkDaFJav50vz_NfMAuMbIxyjAt1w6X2hTcenHAiGM4hMwxlFAvZCi4PSgI4-xhI3AhXNbhFBCwugcjIIkIiwmaAzMwtRawnmXWbNRJbznTmXQ1HBa6MY43gtrnPOWun7rFx-6KSD9_vx6KYzbFWZTtvJQsLbamUy3FVzxsoHcQQ5ntt3AmSr1u7IdXHWuUdUlOMt56dTVcU7A6-PDejr3ls9Pi-nd0uMkDBovVDwnNGK5yGgiWCR5SAkShCYSCYUUUUzyWCGRKBwnWUZx_5okjFLBaRCHZAKCoVfuz7cqT3dWV9x2KUbpnl7a00sHeumRXh-6GUK7VlQq-4v84uoN_mDYh7emtXX_w3-NP6RUf0c</recordid><startdate>20180409</startdate><enddate>20180409</enddate><creator>Martínez-Martínez, Mayte</creator><creator>Rodríguez-Berna, Guillermo</creator><creator>Gonzalez-Alvarez, Isabel</creator><creator>Hernández, M</creator><creator>Corma, Avelino</creator><creator>Bermejo, Marival</creator><creator>Merino, Virginia</creator><creator>Gonzalez-Alvarez, Marta</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-1685-142X</orcidid><orcidid>https://orcid.org/0000-0001-5022-0544</orcidid><orcidid>https://orcid.org/0000-0002-2232-3527</orcidid></search><sort><creationdate>20180409</creationdate><title>Ionic Hydrogel Based on Chitosan Cross-Linked with 6‑Phosphogluconic Trisodium Salt as a Drug Delivery System</title><author>Martínez-Martínez, Mayte ; Rodríguez-Berna, Guillermo ; Gonzalez-Alvarez, Isabel ; Hernández, M ; Corma, Avelino ; Bermejo, Marival ; Merino, Virginia ; Gonzalez-Alvarez, Marta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a342t-4eaf3657fbd69b75ca4630b369c0be0e3e7ca8e0b9e189dd61093c3766ba62843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Administration, Topical</topic><topic>Chitosan - administration & dosage</topic><topic>Chitosan - chemistry</topic><topic>Cross-Linking Reagents - chemistry</topic><topic>Drug Delivery Systems</topic><topic>Gluconates - administration & dosage</topic><topic>Gluconates - chemistry</topic><topic>Humans</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry</topic><topic>Kinetics</topic><topic>Polymers - chemistry</topic><topic>Sodium</topic><topic>Wound Closure Techniques</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martínez-Martínez, Mayte</creatorcontrib><creatorcontrib>Rodríguez-Berna, Guillermo</creatorcontrib><creatorcontrib>Gonzalez-Alvarez, Isabel</creatorcontrib><creatorcontrib>Hernández, M</creatorcontrib><creatorcontrib>Corma, Avelino</creatorcontrib><creatorcontrib>Bermejo, Marival</creatorcontrib><creatorcontrib>Merino, Virginia</creatorcontrib><creatorcontrib>Gonzalez-Alvarez, Marta</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Biomacromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martínez-Martínez, Mayte</au><au>Rodríguez-Berna, Guillermo</au><au>Gonzalez-Alvarez, Isabel</au><au>Hernández, M</au><au>Corma, Avelino</au><au>Bermejo, Marival</au><au>Merino, Virginia</au><au>Gonzalez-Alvarez, Marta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ionic Hydrogel Based on Chitosan Cross-Linked with 6‑Phosphogluconic Trisodium Salt as a Drug Delivery System</atitle><jtitle>Biomacromolecules</jtitle><addtitle>Biomacromolecules</addtitle><date>2018-04-09</date><risdate>2018</risdate><volume>19</volume><issue>4</issue><spage>1294</spage><epage>1304</epage><pages>1294-1304</pages><issn>1525-7797</issn><eissn>1526-4602</eissn><abstract>In this work, 6-phosphogluconic trisodium salt (6-PG–Na+) is introduced as a new aqueous and nontoxic cross-linking agent to obtain ionic hydrogels. Here, it is shown the formation of hydrogels based on chitosan cross-linked with 6-PG–Na+. This formulation is obtained by ionic interaction of cationic groups of polymer with anionic groups of the cross-linker. These hydrogels are nontoxic, do not cause dermal irritation, are easy to extend, and have an adequate adhesion force to be applied as polymeric film over the skin. This formulation exhibits a first order release kinetic and can be applied as drug vehicle for topical administration or as wound dressing for wound healing. The primary goal of this communication is to report the identification and utility of 6-phosphogluconic trisodium salt (6-PG–Na+) as a nontoxic cross-linker applicable for cationic polymers.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>29537830</pmid><doi>10.1021/acs.biomac.8b00108</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1685-142X</orcidid><orcidid>https://orcid.org/0000-0001-5022-0544</orcidid><orcidid>https://orcid.org/0000-0002-2232-3527</orcidid></addata></record> |
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| ispartof | Biomacromolecules, 2018-04, Vol.19 (4), p.1294-1304 |
| issn | 1525-7797 1526-4602 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Administration, Topical Chitosan - administration & dosage Chitosan - chemistry Cross-Linking Reagents - chemistry Drug Delivery Systems Gluconates - administration & dosage Gluconates - chemistry Humans Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Kinetics Polymers - chemistry Sodium Wound Closure Techniques Wound Healing - drug effects |
| title | Ionic Hydrogel Based on Chitosan Cross-Linked with 6‑Phosphogluconic Trisodium Salt as a Drug Delivery System |
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