Cu 2+ -Pyropheophorbide a-Cystine Conjugate: Synergistic Photodynamic/Chemodynamic Therapy and Glutathione Depletion Improves the Antitumor Efficacy and Downregulates the Hypoxia-Inducing Factor

Cancer immune escape, metastasis, recurrence, and multidrug resistance are all associated with hypoxia in the tumor microenvironment (TME). We synthesized a CuPPaCC conjugate for reactive oxygen species (ROS)-mediated cancer therapy. CuPPaCC continuously produced cytotoxic ROS and oxygen through a p...

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Veröffentlicht in:	Bioconjugate chemistry 2023-07, Vol.34 (7), p.1336-1347
Hauptverfasser:	Su, Zhongping, Xu, Haiying, Zhang, Hui, Jin, Siran, Yang, Ziqing, Yan, Rui, Wang, Zhiqiang, Wu, Xiaodan, Jin, Yingxue
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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