Development of Novel Bis(indolyl)-hydrazide–Hydrazone Derivatives as Potent Microtubule-Targeting Cytotoxic Agents against A549 Lung Cancer Cells

The biological significance of microtubules makes them a validated target of cancer therapy. In this study, we have utilized indole, an important pharmacological scaffold, to synthesize novel bis(indolyl)-hydrazide–hydrazone derivatives (NMK-BH compounds) and recognized NMK-BH3 as the most effectiv...

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Veröffentlicht in:	Biochemistry (Easton) 2016-05, Vol.55 (21), p.3020-3035
Hauptverfasser:	Das Mukherjee, Dipanwita, Kumar, N. Maruthi, Tantak, Mukund P, Das, Amlan, Ganguli, Arnab, Datta, Satabdi, Kumar, Dalip, Chakrabarti, Gopal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - pathology Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Blotting, Western Cell Cycle - drug effects Cell Proliferation - drug effects Cells, Cultured Cytotoxins - chemistry Cytotoxins - pharmacology Fibroblasts - cytology Fibroblasts - drug effects Humans Hydrazones - chemistry Hydrazones - pharmacology Indoles - chemistry Indoles - pharmacology Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Lung Neoplasms - drug therapy Lung Neoplasms - pathology Membrane Potential, Mitochondrial - drug effects Microscopy, Fluorescence Microtubules - drug effects Models, Molecular Tubulin - metabolism Tubulin Modulators - chemistry Tubulin Modulators - pharmacology
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