The Engineered Hexosaminidase Tt OGA-D120N Is an Efficient O -/ N -/ S -Glycoligase That Also Catalyzes Formation and Release of Oxazoline Donors for Cascade Syntheses with Glycosynthases or Transglycosylases

Engineering glycoside hydrolases is a major route to obtaining catalysts forming glycosidic bonds. Glycosynthases, thioglycoligases, and transglycosylases represent the main strategies, each having advantages and drawbacks. Here, we show that an engineered enzyme from the GH84 family, the acid-base...

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Veröffentlicht in:	Biochemistry (Easton) 2023-08, Vol.62 (16), p.2358-2362
Hauptverfasser:	Petersen, Agnes B, Mirbarati, Seyed Hossein, Svensson, Birte, Duus, Jens Ø, Teze, David
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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